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Penn Lab

Publications

UPDATE! Check out our new publication:

Elmasri M, Hunter DW, Winchester G, Bates EE, Aziz W, Van Der Does DM, Karachaliou E, Sakimura K, Penn AC. (2022) Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A. Commun Biol. 5(1):174. doi: 10.1038/s42003-022-03115-3.

2026

  • Nowacka, A., Getz, A. M., Zieger, H. L., Malivert, M., Bessa-Neto, D., Augusto, E., . . . Choquet, D. (2026). Synapse-specific and plasticity-regulated AMPA receptor mobility tunes synaptic integration. Neuron, 114(6), 1083-1101.e14. doi:10.1016/j.neuron.2025.12.004
    Article. .

2024

  • Winchester, G., Steele, O. G., Liu, S., Chagas, A. M., Aziz, W., & Penn, A. (2024). Reproducible supervised learning-assisted classification of spontaneous synaptic waveforms with Eventer. Frontiers in Neuroinformatics, 18, pages. doi:10.3389/fninf.2024.1427642
    Article. .
  • Nowacka, A., Getz, A. M., Zieger, H. L., Bessa-Neto, D., Breillat, C., Daburon, S., . . . Choquet, D. (2024). Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration. doi:10.1101/2024.03.19.584837
    Preprint. .

2023

  • Penn, A. (2023). NMDA receptors and their dysfunction linked to genetic variants. doi:10.69645/qjuv4037
    Presentation. .
  • Stuart, A., Steele, O., Penn, A., & King, S. (2023). The effect of APOE isoform on early life hippocampalactivity following naturalistic behaviour. Poster session presented at the meeting of BNA 2023.
    Poster.

2022

  • Elmasri, M., Lotti, J. S., Aziz, W., Steele, O., Karachaliou, E., Sakimura, K., . . . Penn, A. (2022). Synaptic dysfunction by mutations in GRIN2B: influence of triheteromeric NMDA receptors on gain-of-function and loss-of-function mutant classification. Brain Sciences, 12(6), 789 1-24. doi:10.3390/brainsci12060789
    Article. .
  • Steele, O., Stuart, A., Minkley, L., Shaw, K., Bonnar, O., Anderle, S., . . . King, S. (2022). A multi-hit hypothesis for an APOE4-dependent pathophysiological state. Eur J Neurosci, pages. doi:10.1111/ejn.15685
    Article. .
  • Elmasri, M., Hunter, D. W., Winchester, G., Bates, E., Aziz, W., Van Der Does, D. M., . . . Penn, A. (2022). Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A. Communications Biology, 5(1), 1-17. doi:10.1038/s42003-022-03115-3
    Article. .

2020

  • Elmasri, M., Hunter, D., Winchester, G., Bates, E., Aziz, W., Moolenaar Van Der Does, D., . . . Penn, A. C. (2020). Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A. doi:10.1101/2020.08.06.240010
    Preprint. .

2017

  • Penn, A., Zhang, C. L., Georges, F., Royer, L., Breillat, C., Hosy, E., . . . Choquet, D. (2017). Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature, 549, 384-388. doi:10.1038/nature23658
    Article. .

2015

  • Hafner, A. -S., Penn, A., Grillo-Bosch, D., Retailleau, N., Poujol, C., Philippat, A., . . . Choquet, D. (2015). Lengthening of the stargazin cytoplasmic tail increases synaptic transmission by promoting interaction to deeper domains of PSD-95. Neuron, 86(2), 475-489. doi:10.1016/j.neuron.2015.03.013
    Article. .
  • Constals, A., Penn, A., Compans, B., Toulmé, E., Phillipat, A., Marais, S., . . . Choquet, D. (2015). Glutamate-induced AMPA receptor desensitization increases their mobility and modulates short-term plasticity through unbinding from stargazin. Neuron, 85(4), 787-803. doi:10.1016/j.neuron.2015.01.012
    Article. .

2014

  • Letellier, M., Elramah, S., Mondin, M., Soula, A., Penn, A., Choquet, D., . . . Favereaux, A. (2014). miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling. Nature Neuroscience, 17(8), 1040-1042. doi:10.1038/nn.3762
    Article. .
  • Letellier, M., Elramah, S., Mondin, M., Soula, A., Penn, A., Choquet, D., . . . Favereaux, A. (2014). Erratum: MiR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling (Nature Neuroscience (2014) 17 (1040-1042)). Nature Neuroscience, 17(12), 1841. doi:10.1038/nn1214-1841c
    Article. .

2013

  • Penn, A., Balik, A., & Greger, I. H. (2013). Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system. Frontiers in Neuroscience, 7(61), pages. doi:10.3389/fnins.2013.00061
    Article. .
  • Penn, A., Balik, A., & Greger, I. H. (2013). Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing. Nucleic Acids Research, 41(2), 1113-1123. doi:10.1093/nar/gks1044
    Article. .
  • Balik, A., Penn, A., Nemoda, Z., & Greger, I. H. (2013). Activity-regulated RNA editing in select neuronal subfields in hippocampus. Nucleic Acids Research, 41(2), 1124-1134. doi:10.1093/nar/gks1045
    Article. .

2012

  • Penn, A., Balik, A., Wozny, C., Cais, O., & Greger, I. H. (2012). Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain. Neuron, 76(3), 503-510. doi:10.1016/j.neuron.2012.08.010
    Article. .
  • Sukumaran, M., Penn, A., & Greger, I. H. (2012). AMPA receptor assembly: atomic determinants and built-in modulators. Advances in Experimental Medicine and Biology, 970, 241-264. doi:10.1007/978-3-7091-0932-8_11
    Article. .

2011

  • Rossmann, M., Sukumaran, M., Penn, A., Veprintsev, D. B., Babu, M. M., & Greger, I. H. (2011). Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers. EMBO Journal, 30(5), 959-971. doi:10.1038/emboj.2011.16
    Article. .

2009

  • Penn, A. C., & Greger, I. H. (2009). Sculpting AMPA receptor formation and function by alternative RNA processing.. RNA Biology, 6(5), 517-521. doi:10.4161/rna.6.5.9552
    Article. .

2008

  • Penn, A., Williams, S. R., & Greger, I. H. (2008). Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum. EMBO Journal, 27(22), 3056-3068. doi:10.1038/emboj.2008.222
    Article. .

2007

  • Greger, I. H., Ziff, E. B., & Penn, A. (2007). Molecular determinants of AMPA receptor subunit assembly. Trends in Neurosciences, 30(8), 407-416. doi:10.1016/j.tins.2007.06.005
    Article. .

2005

  • Bosman, E. A., Penn, A. C., Ambrose, J. C., Kettleborough, R., Stemple, D. L., & Steel, K. P. (2005). Multiple mutations in mouse Chd7 provide models for CHARGE syndrome. Human Molecular Genetics, 14(22), 3463-3476. doi:10.1093/hmg/ddi375
    Article. .
  • Hackney, C. M., Mahendrasingam, S., Penn, A., & Fettiplace, R. (2005). The concentrations of calcium buffering proteins in mammalian cochlear hair cells. Journal of Neuroscience, 25(34), 7867-7875. doi:10.1523/JNEUROSCI.1196-05.2005
    Article. .