Publications : Giamas Lab : School of Life Sciences : �鶹ӳ��

Prof Giamas lab publications to date

2026

Robinson, S. D., Haile, B. T., Reily-Bell, M., Iwanowytsch, O., Palmer, S., Nørøxe, D. S., . . . Giamas, G. (2026). Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis. Cell Reports Medicine, pages. doi:10.1016/j.xcrm.2026.102744
Article. .
Lu, J., Huang, X., Yao, H., Filippopoulou, C., Shirazi Nia, R., Gu, X., . . . Giamas, G. (2026). LMTK3 regulates breast cancer angiogenesis via a context-dependent mesenchymal-epithelial transition program. Cancer Gene Therapy. doi:10.1038/s41417-026-01001-2
Article. .
Lu, J., Shirazi Nia, R., Sun, J., Filippopoulou, C., De Vega, D., Hu, P., . . . Giamas, G. (2026). Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer. Biological Reviews. doi:10.1002/brv.70167
Article. .
Wu, H., Zheng, J., Xu, W., Zhou, F., Lenahan, C., Giamas, G., . . . Ji, J. (2026). Blood-brain barrier breakdown in traumatic brain injury: current insights and future directions. Cancer Gene Therapy. doi:10.1038/s41417-026-01027-6
Article. .

2025

Robinson, S. D., Iwanowytsch, O., Palmer, S., Haile, B. T., Filippou, P. S., Reily-Bell, M., . . . Giamas, G. (2025). P05.05.A INTEGRATED MULTI-OMICS AND MULTI-SPECTRAL PROFILING OF PLASMA EXTRACELLULAR VESICLES REVEALS HIGHLY ACCURATE LIQUID BIOPSY BIOMARKERS FOR GLIOMA DIAGNOSIS.. Neuro-Oncology, 27(Supplement_3), iii65. doi:10.1093/neuonc/noaf193.210
Article. .
Robinson, S. D., Lammy, S., Heppner, P., Forner, S., Thompson, M., Dulley, L., . . . Critchley, G. (2025). P17.12.B INVESTIGATING SHORT TERM (&lt;6 MONTHS) SURVIVORS OF GLIOBLASTOMA - AN ANALYSIS OF THE HISTO-MOL GBM COLLABORATIVE DATABASE.. Neuro-Oncology, 27(Supplement_3), iii157. doi:10.1093/neuonc/noaf193.528
Article. .
Robinson, S., Iwanowytsch, O., Filippou, P., Renaut, J., Haile, B., Jung, J., . . . Giamas, G. (2025). DEVELOPING AN EXTRACELLULAR VESICLE-BASED MULTI-OMIC LIQUID BIOPSY BIOMARKER SIGNATURE OF GLIOMA USING SAMPLES FROM THE GENOMICS ENGLAND BIOBANK. Neuro-Oncology, 27(Supplement_2), ii9-ii10. doi:10.1093/neuonc/noaf185.036
Article. .
Robinson, S., Farrell, S., Chaudhary, A., Lammy, S., Lee, N. S. J., Byers, A., . . . Collaborative, H. -M. G. B. M. (2025). THE LANDSCAPE OF SECOND LINE (AND BEYOND) TREATMENTS FOR GLIOBLASTOMA (IDH WILDTYPE) IN THE UK IN 2021: AN UPDATE FROM THE HISTO-MOL GBM COLLABORATIVE. Neuro-Oncology, 27(Supplement_2), ii7. doi:10.1093/neuonc/noaf185.025
Article. .
Critchley, G., Reily-Bell, M., Robinson, S., Saraiva, A., Taha, A., Giamas, G., . . . Katare, R. (2025). INVESTIGATION OF A LIQUID BIOPSY EXTRACELLULAR VESICLE BIOMARKER FOR BRAIN TUMOURS – THE ROLE OF A COMMON INﬂAMMATORY PATHWAY. Neuro-Oncology, 27(Supplement_2), ii17-ii18. doi:10.1093/neuonc/noaf185.067
Article. .
Samuels, M., Besta, S., Betrán, A. L., Nia, R. S., Xie, X., Gu, X., . . . Giamas, G. (2025). CRISPR screening approaches in breast cancer research. Cancer and Metastasis Reviews, 44(3). doi:10.1007/s10555-025-10275-1
Article. .
Chen, Y., Ding, K., Zheng, S., Gao, S., Xu, X., Wu, H., . . . Ji, J. (2025). Post-translational modifications in DNA damage repair: mechanisms underlying temozolomide resistance in glioblastoma.. Oncogene, 1-12. doi:10.1038/s41388-025-03454-5
Article. .
Samuels, M., Karakostas, C., Besta, S., Betrán, A. L., Tsilingiri, K., Turner, C., . . . Giamas, G. (2025). LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer. Molecular Cancer, 24(1), pages. doi:10.1186/s12943-025-02346-2
Article. .
Robinson, S., Filippopoulou, C., Besta, S., Samuels, M., Betrán, A. L., Ajamieh, M. A., . . . Giamas, G. (2025). Spatial biology – unravelling complexity within the glioblastoma microenvironment. Trends in Molecular Medicine, pages. doi:10.1016/j.molmed.2025.01.014
Article. .

2024

Filippopoulou, C., & Giamas, G. (2024). Targeting LMTK3 in ovarian cancer: a dual role in prognosis and therapy. Molecular Therapy Oncology, 32(4), pages. doi:10.1016/j.omton.2024.200902
Article. .
Robinson, S. D., Clark, M., MacColl, J., Forner, S., Wong, A., Srimat Tirumala, L. N. K., . . . Chandy, E. (2024). OS12.6.A MOLECULAR GLIOBLASTOMAS - BETTER PROGNOSIS AFTER CORRECTING FOR TREATMENT DIFFERENCES. Neuro-Oncology, 26(Supplement_5), v29-v30. doi:10.1093/neuonc/noae144.087
Article. .
Robinson, S. D., Hooper, C., MacColl, J., Ryan, K., Ajah, H., Williams, S. T., . . . Critchley, G. (2024). P18.23.A GLIOBLASTOMA IN OLDER ADULTS, A NEED FOR BOLDER TREATMENT IN SELECTED PATIENTS?. Neuro-Oncology, 26(Supplement_5), v101. doi:10.1093/neuonc/noae144.339
Article. .
Robinson, S. D., Clark, M., Rathbone, M., Black, L., Kovacs, B., Augustine, P., . . . Critchley, G. (2024). P18.22.B GLIOBLASTOMA IN 2021, DEVELOPING A LARGE INDIVIDUAL PATIENT DATABASE TO INVESTIGATE OUTCOMES AND TREATMENT PATTERNS. Neuro-Oncology, 26(Supplement_5), v100-v101. doi:10.1093/neuonc/noae144.338
Article. .
Robinson, D. S., Ryan, D. K., Black, D. L., Forner, D. S., Hatton, D. N. L., Hatton, D. R., . . . Critchley, P. G. (2024). MANAGEMENT OF THE OLDER PATIENT WITH GLIOBLASTOMA IN THE UK: AN INITIAL REPORT FROM THE HISTO-MOL GBM COLLABORATIVE. Neuro-Oncology, 26(Supplement_7), vii5-vii6. doi:10.1093/neuonc/noae158.019
Article. .
Robinson, D. S., Ryan, D. K., Black, D. L., Forner, D. S., Hatton, D. N. L., Hatton, D. R., . . . Critchley, P. G. (2024). GLIOBLASTOMA IN THE UK POST WHO CNS 5: INITIAL ﬁNDINGS FROM THE HISTO-MOL GBM COLLABORATIVE. Neuro-Oncology, 26(Supplement_7), vii2-vii3. doi:10.1093/neuonc/noae158.007
Article. .
Vella, D. V., Ditsiou, D. A., Chalari, D. A., Eravci, D. M., Wooller, D. S. K., Gagliano, P. T., . . . Giamas, P. G. (2024). KINOME-WIDE SYNTHETIC LETHAL SCREEN IDENTIﬁES PANK4 AS A MODULATOR OF TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA. Neuro-Oncology, 26(Supplement_7), vii5. doi:10.1093/neuonc/noae158.017
Article. .
Robinson, S. D., Samuels, M., Jones, W., Stewart, N., Eravci, M., Mazarakis, N. K., . . . Giamas, G. (2024). Confirming size-exclusion chromatography as a clinically relevant extracellular vesicles separation method from 1mL plasma through a comprehensive comparison of methods. BMC Methods, 1(1), pages. doi:10.1186/s44330-024-00007-2
Article. .
Robinson, S. D., De Boisanger, J., Pearl, F., Critchley, G., Rosenfelder, N., & Giamas, G. (2024). A brain metastasis liquid biopsy: where are we now?. Neuro-Oncology Advances, 6(1), pages. doi:10.1093/noajnl/vdae066
Article. .
Samuels, M., Jones, W., Turner, C., & Giamas, G. (2024). Abstract PO1-25-01: LMTK3 promotes macrophage M2 polarisation and suppresses monocyte infiltration in breast cancer by altering the proteomic cargo of exosomes. Cancer Research, 84(9_Supplement). doi:10.1158/1538-7445.sabcs23-po1-25-01
Article. .
Cho, N., Kontou, G., Smalley, J. L., Bope, C., Dengler, J., Montrose, K., . . . Moss, S. J. (2024). The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl<sup>−</sup> extrusion. iScience, 27(4), pages. doi:10.1016/j.isci.2024.109512
Article. .
Torres-Gonzalez, L., Soni, S., Yang, Y., Smbatyan, G., Lo, J. H., Mittal, P., . . . Lenz, H. -J. (2024). Abstract 6832: Gender specific role of LMTK3 in neuronal-tumor microenvironment crosstalk in CRC. Cancer Research, 84(6_Supplement), 6832. doi:10.1158/1538-7445.am2024-6832
Article. .
Samuels, M., & Giamas, G. (2024). MISEV2023: shaping the future of EV research by enhancing rigour, reproducibility and transparency. Cancer Gene Therapy, 1-3. doi:10.1038/s41417-024-00759-7
Article. .
Mazarakis, N. K., Robinson, S. D., Sinha, P., Koutsarnakis, C., Komaitis, S., Stranjalis, G., . . . Giamas, G. (2024). Management of glioblastoma in elderly patients: a review of the literature. Clinical and Translational Radiation Oncology, 46, pages. doi:10.1016/j.ctro.2024.100761
Article. .
Vella, V., Ditsiou, A., Chalari, A., Eravci, M., Wooller, S. K., Gagliano, T., . . . al., E. (2024). Kinome-wide synthetic lethal screen identifies PANK4 as a modulator of temozolomide resistance in glioblastoma. Advanced Science, pages. doi:10.1002/advs.202306027
Article. .
Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., . . . Anderson, J. D. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), pages. doi:10.1002/jev2.12404
Article. .
Malavasi, E., Adamo, M., Zamprogno, E., Vella, V., Giamas, G., & Gagliano, T. (2024). Decoding the Tumour Microenvironment: Molecular Players, Pathways, and Therapeutic Targets in Cancer Treatment. Cancers, 16(3), pages. doi:10.3390/cancers16030626
Article. .
Mórotz, G. M., Bradbury, N. A., Caluseriu, O., Hisanaga, S. -I., Miller, C. C. J., Swiatecka-Urban, A., . . . Giamas, G. (2024). A revised nomenclature for the lemur family of protein kinases. Communications Biology, 7, pages. doi:10.1038/s42003-023-05671-8
Article. .
Torres-Gonzalez, L., Battaglin, F., Soni, S., Baca, Y., Xiu, J., Walker, P., . . . Lenz, H. J. (2024). LMTK3 gene expression and the molecular landscape of colorectal cancer (CRC).. Journal of Clinical Oncology, 42(3), 172. doi:10.1200/JCO.2024.42.3_suppl.172
Article. .

2023

Robinson, S., Samuels, M., Jones, W., Gilbert, D., Critchley, G., & Giamas, G. (2023). Shooting the messenger: a systematic review investigating extracellular vesicle isolation and characterisation methods and their influence on understanding extracellular vesicles-radiotherapy interactions in glioblastoma. BMC Cancer, 23(1), pages. doi:10.1186/s12885-023-11437-6
Article. .
Du, Z., Zhang, T., Lin, Y., Dong, G., Li, A., Wang, Z., . . . Peng, L. (2023). A prognostic model of drug tolerant persister-related genes in lung adenocarcinoma based on single cell and bulk RNA sequencing data. Heliyon, 9(11), pages. doi:10.1016/j.heliyon.2023.e20708
Article. .
Samuels, M., Jones, W., Towler, B., Turner, C., Robinson, S., & Giamas, G. (2023). The role of non-coding RNAs in extracellular vesicles in breast cancer and their diagnostic implications. Oncogene, 42(41), 3017-3034. doi:10.1038/s41388-023-02827-y
Article. .
Malavasi, E., Giamas, G., & Gagliano, T. (2023). Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment. Cancer Gene Therapy, 30(7), 932-935. doi:10.1038/s41417-023-00618-x
Article. .
Vella, V., Ditsiou, A., Chalari, A., Eravci, M., Wooler, S. K., Gagliano, T., . . . Zhang, Y. (2023). Kinome-wide synthetic lethal screen identifies PANK4 as modulator of resistance in glioblastoma . doi:10.21203/rs.3.rs-2731966/v1
Preprint. .
Falcinelli, M., Al-Hity, G., Baron, S., Mampay, M., Allen, M. C., Samuels, M., . . . Flint, M. S. (2023). Propranolol reduces IFN-? driven PD-L1 immunosuppression and improves anti-tumour immunity in ovarian cancer. Brain, Behavior, and Immunity, 110, 1-12. doi:10.1016/j.bbi.2023.02.011
Article. .
Agnarelli, A., Betran, A. L., Papakyriakou, A., Vella, V., Samuels, M., Papanastasopoulos, P., . . . Giamas, G. (2023). The inhibitory properties of a novel, selective LMTK3 kinase inhibitor. International Journal of Molecular Sciences, 24(1), e865 1-15. doi:10.3390/ijms24010865
Article. .

2022

Liang, F., Peng, L., Wu, Z., Giamas, G., & Stebbing, J. (2022). Design and reporting of phase III oncology trials with prospective biomarker validation. Journal of the National Cancer Institute, djac210 1-7. doi:10.1093/jnci/djac210
Article. .
Giamas, G., Cilibrasi, C., Simon, T., Stewart, N., Critchley, G., & Eravci, M. (2022). BIOM-06. Identification of an inflammatory biomarker signature in plasma-derived extracellular vesicles of glioblastoma patients. Neuro-Oncology, 24(7), vii5. doi:10.1093/neuonc/noac209.016
Article. .
Cilibrasi, C., Simon, T., Vintu, M., Tolias, C., Samuels, M., Mazarakis, N., . . . Giamas, G. (2022). Identification of an Inflammatory Biomarker Signature in Plasma-Derived Extracellular Vesicles of Glioblastoma Patients. Neuro-Oncology, 24(Supplement_4), iv6-iv7. doi:10.1093/neuonc/noac200.027
Article. .
Agnarelli, A., Vella, V., Samuels, M., Papanastasopoulos, P., & Giamas, G. (2022). Incorporating immunotherapy in the management of gastric cancer: molecular and clinical implications. Cancers, 14(18), e4378 1-25. doi:10.3390/cancers14184378
Article. .
Thaker, P., Flint, M., Giamas, G., Falcinelli, M., Alhity, G., Mampay, M., . . . Samuels, M. (2022). Pharmacologic inhibition of beta-adrenergic receptors decreases PD-L1 mediated immunosuppression and improves anti-tumor immune signature in ovarian cancer (126). Gynecologic Oncology, 166, S80. doi:10.1016/s0090-8258(22)01352-x
Article. .
Lane, R., Cilibrasi, C., Chen, J., Shah, K., Messuti, E., Mazarakis, N. K., . . . Giamas, G. (2022). PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38MAPK signalling. Oncogene, 1-15. doi:10.1038/s41388-022-02294-x
Article. .
Wang, Z., Zhu, L., Li, K., Sun, Y., Giamas, G., Stebbing, J., . . . Yu, Z. (2022). Alternative splicing events in tumor immune infiltration in renal clear cell carcinomas. Cancer Gene Therapy, pages. doi:10.1038/s41417-022-00426-9
Article. .
Giamas, G., & Spencer, J. (2022). WO/2022/053838, Small molecule inhibitors of Lemur tyrosine kinase 3 (LTK).
Patent. .
Giamas, G., & Spencer, J. (2022). WO/2022/053838, Small molecule inhibitors of Lemur tyrosine kinase 3 (LTK).
Patent. .
Samuels, M., Cilibrasi, C., Papanastasopoulos, P., & Giamas, G. (2022). Extracellular vesicles as mediators of therapy resistance in breast cancer microenvironment. Biomolecules, 12(1), 1-40. doi:10.3390/biom12010132
Article. .
Cilibrasi, C., Simon, T., Vintu, M., Tolias, C., Samuels, M., Mazarakis, N. K., . . . Giamas, G. (2022). Definition of an inflammatory biomarker signature in plasma-derived extracellular vesicles of glioblastoma patients. Biomedicines, 10(1), 1-15. doi:10.3390/biomedicines10010125
Article. .

2021

Zhu, L., Wang, Z., Sun, Y., Giamas, G., Stebbing, J., Yu, Z., & Peng, L. (2021). A prediction model using alternative splicing events and the immune microenvironment signature in lung adenocarcinoma. Frontiers in Oncology, 11, 1-14. doi:10.3389/fonc.2021.778637
Article. .
Brown, C., Simon, T., Cilibrasi, C., Lynch, P., Harries, R., Graf, A. A., . . . King, A. (2022). Tuneable synthetic reduced graphene oxide scaffolds elicit high levels of three-dimensional glioblastoma interconnectivity in vitro. Journal of Materials Chemistry B, 10(30), 373-383. doi:10.1039/d1tb01266e
Article. .
Vella, V., Giamas, G., & Ditsiou, A. (2021). Diving into the dark kinome: lessons learned from LMTK3. Cancer Gene Therapy, pages. doi:10.1038/s41417-021-00408-3
Article. .
Klionsky, D. J. (2021). Look youse guys and gals, dat just ain't right.. Autophagy, 17(12), 3895-3896. doi:10.1080/15548627.2021.1999162
Article. .
Cilibrasi, C., Papanastasopoulos, P., Samuels, M., & Giamas, G. (2021). Reconstituting immune surveillance in breast cancer: molecular pathophysiology and current immunotherapy strategies. International Journal of Molecular Sciences, 22(21), 1-20. doi:10.3390/ijms222112015
Article. .
Peng, L., Li, J., Wu, J., Xu, B., Wang, Z., Giamas, G., . . . Yu, Z. (2021). A pan-cancer analysis of SMARCA4 alterations in human cancers. Frontiers in Immunology, 12, 1-15. doi:10.3389/fimmu.2021.762598
Article. .
Burn, L., Gutowski, N., Whatmore, J., Giamas, G., & Pranjol, M. Z. I. (2021). The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier. Frontiers in Bioscience-Landmark, 26(9), 590-601. doi:10.52586/4969
Article. .
Ditsiou, A., Gagliano, T., Samuels, M., Vella, V., Tolias, C., & Giamas, G. (2021). The multifaceted role of lemur tyrosine kinase 3 in health and disease. Open biology, 11(9), 1-12. doi:10.1098/rsob.210218
Article. .
Chrysostomou, S., Roy, R., Prischi, F., Thamlikitkul, L., Chapman, K. L., Mufti, U., . . . others. (2021). Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer. Science Translational Medicine, 13(602), pages. doi:10.1126/scitranslmed.aba4627
Article. .
Lepore, A., Choy, P. M., Lee, N. C. W., Carella, M. A., Favicchio, R., Briones-Orta, M. A., . . . Papa, S. (2021). Phosphorylation and stabilization of PIN1 by JNK promote intrahepatic cholangiocarcinoma growth. Hepatology, 74(5), 2561-2579. doi:10.1002/hep.31983
Article. .
Giamas, G., & Gagliano, T. (2022). Cancer gene therapy 2020: highlights from a challenging year. Cancer Gene Therapy, 29(1), 1-3. doi:10.1038/s41417-021-00340-6
Article. .
Cilibrasi, C., Ditsiou, A., Papakyriakou, A., Mavridis, G., Eravci, M., Stebbing, J., . . . Giamas, G. (2021). Correction to: LMTK3 inhibition affects microtubule stability. Molecular Cancer, 20(1), 1-3. doi:10.1186/s12943-021-01353-3
Article. .
Cilibrasi, C., Ditsiou, A., Papakyriakou, A., Mavridis, G., Eravci, M., Stebbing, J., . . . Giamas, G. (2021). LMTK3 inhibition affects microtubule stability. Molecular Cancer, 20, 1-6. doi:10.1186/s12943-021-01345-3
Article. .
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., . . . others. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 1-382. doi:10.1080/15548627.2020.1797280
Article. .
Stebbing, J., Zhang, H., Xu, Y., Lit, L. C., Green, A. R., Grothey, A., . . . Giamas, G. (2021). Correction: KSR1 regulates BRCA1 degradation and inhibits breast cancer growth (Oncogene, (2015), 34, 16, (2103-2114), 10.1038/onc.2014.129). Oncogene. doi:10.1038/s41388-021-01794-6
Article. .

2020

Ditsiou, A., Cilibrasi, C., Simigdala, N., Harris, L., Vella, V., Gagliano, T., . . . others. (2020). The structure-function relationship of oncogenic LMTK3. Science Advances, 6(46), 1-19. doi:10.1126/sciadv.abc3099
Article. .
Shah, K., Gagliano, T., Garland, L., O’Hanlon, T., Bortolotti, D., Gentili, V., . . . Dean, M. (2020). Androgen receptor signaling regulates the transcriptome of prostate cancer cells by modulating global alternative splicing. Oncogene, pages. doi:10.1038/s41388-020-01429-2
Article. .
Harries, R., Brown, C., Ogilvie, S., Large, M., Graf, A. A., Clifford, K., . . . King, A. (2020). Langmuir films of layered nanomaterials: edge interactions and cell culture applications. Journal of Physical Chemistry B, pages. doi:10.1021/acs.jpcb.0c05573
Article. .
Simon, T., Jackson, E., & Giamas, G. (2020). Breaking through the glioblastoma micro-environment via extracellular vesicles. Oncogene, 1-14. doi:10.1038/s41388-020-1308-2
Article. .
Simon, T., Kumaran, A., Veselu, D. -F., & Giamas, G. (2020). Three method-combination protocol for improving purity of extracellular vesicles. International Journal of Molecular Sciences, 21(9), pages. doi:10.3390/ijms21093071
Article. .
Martelli, C., King, A., Simon, T., & Giamas, G. (2020). Graphene-induced transdifferentiation of cancer stem cells as a therapeutic strategy against glioblastoma. ACS Biomaterials Science & Engineering, pages. doi:10.1021/acsbiomaterials.0c00197
Article. .
Gagliano, T., Shah, K., Gargani, S., Lao, L., Alsaleem, M., Chen, J., . . . others. (2020). PIK3Cd expression by fibroblasts promotes triple-negative breast cancer progression. Journal of Clinical Investigation, 130(6), 3188-3204. doi:10.1172/JCI128313
Article. .
Giamas, G. (2020). Reviewer recognition. Cancer gene therapy, 27, pages. doi:10.1038/s41417-020-0168-9
Article. .
Giamas, G. (2020). [Editorial] Cancer gene therapy: vision and strategy for the new decade. Cancer Gene Therapy, 27, 115 ( pages). doi:10.1038/s41417-020-0169-8
Article. .

2019

Shah, K., Gagliano, T., Garland, L., O’Hanlon, T., Bortolotti, D., Gentili, V., . . . Dean, M. (2019). Androgen Receptor Signaling Regulates the Transcriptome of Prostate Cancer Cells by Modulating Global Alternative Splicing. doi:10.1101/828707
Preprint. .
Bresciani, G., Hofland, L. J., Dogan, F., Giamas, G., Gagliano, T., & Zatelli, M. C. (2019). Evaluation of spheroid 3D culture methods to study a pancreatic neuroendocrine neoplasm cell line. Frontiers in Endocrinology, 10, 1-10. doi:10.3389/fendo.2019.00682
Article. .
Chrysostomou, S., Roy, R., Prischi, F., Chapman, K., Mufti, U., Mauri, F., . . . Pardo, O. (2019). Abstract 1775: Targeting RSK4 prevents both chemoresistance and metastasis in lung cancer. In Cancer Research Vol. 79 (pp. 1775). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2019-1775
Conference publication. .
Chrysostomou, S., Roy, R., Prischi, F., Chapman, K., Mufti, U., Mauri, F., . . . Pardo, O. (2019). Abstract 1775: Targeting RSK4 prevents both chemoresistance and metastasis in lung cancer. In Molecular and Cellular Biology / Genetics (pp. 1775). American Association for Cancer Research. doi:10.1158/1538-7445.sabcs18-1775
Conference publication. .
Rani, A., Stebbing, J., Giamas, G., & Murphy, J. (2019). Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy. Frontiers in Endocrinology, 10(245), 1-32. doi:10.3389/fendo.2019.00245
Article. .
Bresciani, G., Ditsiou, A., Cilibrasi, C., Vella, V., Rea, F., Schiavon, M., . . . Gagliano, T. (2019). EGF and IGF1 affect Sunitinib activity in BP-NEN: new putative targets beyond VEGFR?. Endocrine Connections, 8(6), 680-690. doi:10.1530/EC-19-0192
Article. .
Bresciani, G., Ditsiou, A., Cilibrasi, C., Vella, V., Rea, F., Schiavon, M., . . . Gagliano, T. (2019). EGFR and IGF1R affect Sunitinib activity: novel targets for Broncho-Pulmonary Neuroendocrine Neoplasm treatment. In Endocrine Abstracts (pp. pages). Lyon, France: Bioscientifica. doi:10.1530/endoabs.63.p464
Conference publication. .
Bresciani, G., Hofland, L. J., Giamas, G., Gagliano, T., & Zatelli, M. C. (2019). Available 3D cultures methods: study on a Pancreatic Neuroendocrine Neoplasm cell line. Endocrine Abstracts, pages. doi:10.1530/endoabs.63.p40
Article. .
Bresciani, G., Ditsiou, A., Cilibrasi, C., Vella, V., Giamas, G., Zatelli, M. C., & Gagliano, T. (2019). Influence of Tumor Microenviroment in response modulation to treatment in human BP-NENs. Endocrine Abstracts, pages. doi:10.1530/endoabs.63.p38
Article. .
Gagliano, T., Shah, K., Gargani, S., Lao, L., Alsaleem, M., Chen, J., . . . Giamas, G. (2019). Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression. doi:10.1101/822049
Preprint. .

2018

Wendler, F., Purice, T. -M., Simon, T., Stebbing, J., & Giamas, G. (2021). The LMTK-family of kinases: emerging important players in cell physiology and pathogenesis. BBA - Molecular Basis of Disease, 1867(9), 1-7. doi:10.1016/j.bbadis.2018.12.023
Article. .
Brandao, M., Simon, T., Critchley, G., & Giamas, G. (2019). Astrocytes, the rising stars of the glioblastoma microenvironment. Glia, 67(5), 779-790. doi:10.1002/glia.23520
Article. .
Simon, T., Pinioti, S., Schellenberger, P., Rajeeve, V., Wendler, F., Cutillas, P. R., . . . Giamas, G. (2018). [Letter to editor] Shedding of bevacizumab in tumour cells derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma. Molecular Cancer, 17(132), 1-7. doi:10.1186/s12943-018-0878-x
Article. .
Gagliano, T., Vella, V., Bienkowska, K., Ditsiou, A., & Giamas, G. (2018). Abstract 2087: Fibroblast-kinome siRNA screening identifies PIK3Cδ as a mediator of Triple-negative breast cancer (TNBC) invasion. In Cancer Research Vol. 78 (pp. 2087). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2018-2087
Conference publication. .
Gagliano, T., Vella, V., Bienkowska, K., Ditsiou, A., & Giamas, G. (2018). Fibroblast-kinome silencing to identifies putative mediator of Triple-negative breast cancer (TNBC) invasion. Endocrine Abstracts, pages. doi:10.1530/endoabs.56.p654
Article. .
Ditsiou, A., Gagliano, T., Prodromou, C., Gascon, J., Mumford, S., Grand, D. L., & Giamas, G. (2018). Targeting treatment resistance in breast cancer subtypes via LMTK3 inhibition. In Endocrine Abstracts (pp. 651 ( pages)). Barcelona, Spain: Bioscientifica. doi:10.1530/endoabs.56.p651
Conference publication. .
Stebbing, J., Shah, K., Lit, L. C., Gagliano, T., Ditsiou, A., Wang, T., . . . Giamas, G. (2018). LMTK3 confers chemo-resistance in breast cancer. Oncogene, 37(23), 3113-3130. doi:10.1038/s41388-018-0197-0
Article. .
Giamas, G., Vella, V., Ditsiou, A., & Teresa, T. (2018). Abstract P5-03-04: Not presented. In Cancer Research Vol. 78. American Association for Cancer Research (AACR). doi:10.1158/1538-7445.sabcs17-p5-03-04
Conference publication. .

2017

Gagliano, T., Ditsiou, A., Grothey, A., & Giamas, G. (2017). ER status heterogeneity in breast cancer: role in response to endocrine treatment. Endocrine Abstracts, pages. doi:10.1530/endoabs.49.ep785
Article. .
Giamas, G., Grothey, T., Grothey, A., & Stebbing, J. (2017). Abstract P4-03-02: Stromal kinome screening identifies a novel regulatory kinase implicated in fibroblast-mediated progression of invasion in triple negative breast cancer tumours. In Cancer Research Vol. 77. American Association for Cancer Research (AACR). doi:10.1158/1538-7445.sabcs16-p4-03-02
Conference publication. .
Simon, T., Gagliano, T., & Giamas, G. (2017). Direct effects of anti-angiogenic therapies on tumor cells: VEGF signaling. Trends in Molecular Medicine, 23(3), 282-292. doi:10.1016/j.molmed.2017.01.002
Article. .

2016

Gagliano, T., Simon, T., & Giamas, G. (2016). miRNA transported by exosomes: a key machinery in tumor microenvironment mediated chemoresistance. Translational Cancer Research, 5(S7), S1479-S1482. doi:10.21037/tcr.2016.12.40
Article. .
Wendler, F., Favicchio, R., Simon, T., Alifrangis, C., Stebbing, J., & Giamas, G. (2017). Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention. Oncogene, 36(7), 877-884. doi:10.1038/onc.2016.253
Article. .
Favicchio, R., Angelopoulos, N., Brickute, D., Fortt, R., Twyman, F., Giamas, G., . . . Aboagye, E. O. (2016). Abstract 4235: Choline metabolism is an early predictor of EGFR-mediated survival in NSCLC. In Cancer Research Vol. 76 (pp. 4235). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2016-4235
Conference publication. .
Lucchiari, G., Zhang, H., Nunes, J., Xu, Y., Grothey, A., Stebbing, J., & Giamas, G. (2016). Abstract 185: Role of phosphorylation in Lmtk3 activation and its contribution in breast cancer progression. In Cancer Research Vol. 76 (pp. 185). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2016-185
Conference publication. .
Angelopoulos, N., Abdallah, S., & Giamas, G. (2016). Advances in integrative statistics for logic programming. International Journal of Approximate Reasoning, 78, 103-115. doi:10.1016/j.ijar.2016.06.008
Article. .
Wendler, F., Stamp, G., & Giamas, G. (2016). Tumor–stromal cell communication: small vesicles signal big changes. Trends in Cancer, 2(7), 326-329. doi:10.1016/j.trecan.2016.05.007
Article. .
Nunes, J., Zhang, H., Angelopoulos, N., Chhetri, J., Osipo, C., Grothey, A., . . . Giamas, G. (2016). ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation. Oncotarget, 7(19), 27599-27612. doi:10.18632/oncotarget.8504
Article. .
Angelopoulos, N., Stebbing, J., Xu, Y., Giamas, G., & Zhang, H. (2016). Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer. Data in Brief, 7, 740-746. doi:10.1016/j.dib.2016.03.024
Article. .
Jacob, J., Favicchio, R., Karimian, N., Mehrabi, M., Harding, V., Castellano, L., . . . Giamas, G. (2016). LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5. Cancer Letters, 372(1), 137-146. doi:10.1016/j.canlet.2015.12.026
Article. .
Favicchio, R., Thepaut, C., Zhang, H., Arends, R., Stebbing, J., & Giamas, G. (2016). Strategies in functional proteomics: unveiling the pathways to precision oncology. Cancer Letters, 382(1), 86-94. doi:10.1016/j.canlet.2016.01.049
Article. .

2015

Rampias, T., Favicchio, R., Stebbing, J., & Giamas, G. (2016). Targeting tumor-stroma crosstalk: the example of the NT157 inhibitor. Oncogene, 35(20), 2562-2564. doi:10.1038/onc.2015.392
Article. .
Schofield, G. M., Urch, C. E., Stebbing, J., & Giamas, G. (2016). Reply: when does a human being die?. QJM, 109(2), 146 ( pages). doi:10.1093/qjmed/hcv164
Article. .
Xu, Y., Zhang, H., Nguyen, V., Angelopoulos, N., Nunes, J., Reid, A., . . . Giamas, G. (2015). LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer. Cell Reports, 12(5), 837-849. doi:10.1016/j.celrep.2015.06.073
Article. .
Angelopoulos, N., Abdallah, S., & Giamas, G. (2015). Advances in integrating statistical inference. In CEUR Workshop Proceedings Vol. 1413 (pp. 9-18). Cork, Ireland: CEUR Workshop Proceedings.
Conference publication. .
Stebbing, J., Zhang, H., Xu, Y., Grothey, A., Ajuh, P., Angelopoulos, N., & Giamas, G. (2015). Reprogramming of the tyrosine kinase-regulated proteome in breast cancer by combined use of RNAi and SILAC quantitative proteomics. Molecular and Cellular Proteomics : MCP, 14, 2479-2492. doi:10.1074/mcp.M115.048090
Article. .
Zhang, H., Angelopoulos, N., Xu, Y., Grothey, A., Nunes, J., Stebbing, J., & Giamas, G. (2015). Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer. Breast Cancer Research and Treatment, 151(3), 555-568. doi:10.1007/s10549-015-3443-y
Article. .
Stebbing, J., Zhang, H., Xu, Y., Lit, L. C., Green, A. R., Grothey, A., . . . Giamas, G. (2015). KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. Oncogene, 34(16), 2103-2114. doi:10.1038/onc.2014.129
Article. .
Papanastasopoulos, P., & Giamas, G. (2015). mTOR inhibition in breast cancer. Breast Cancer Management, 4(2), 67-70. doi:10.2217/BMT.14.54
Article. .
Benhaim, L., Zhang, W., Wakatsuki, T., Yang, D., Gerger, A., Bohanes, P., . . . Lenz, H. J. (2015). Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERa-positive advanced breast cancer. The Pharmacogenomics Journal, 15(3), 235-240. doi:10.1038/tpj.2014.58
Article. .
Zhang, H., Stebbing, J., & Giamas, G. (2015). The many-faced KSR1: a tumor suppressor in breast cancer. Oncoscience, 2(8), 669-670. doi:10.18632/oncoscience.219
Article. .
Angelopoulos, N., & Giamas, G. (2015). A logical approach to working with biological databases. In Ceur Workshop Proceedings Vol. 1433.
Conference publication.

2014

Zhang, H., Xu, Y., Papanastasopoulos, P., Stebbing, J., & Giamas, G. (2014). Broader implications of SILAC-based proteomics for dissecting signaling dynamics in cancer. Expert Review of Proteomics, 11(6), 713-731. doi:10.1586/14789450.2014.971115
Article. .
Schofield, G. M., Urch, C. E., Stebbing, J., & Giamas, G. (2015). When does a human being die?. QJM: An International Journal of Medicine, 108(8), 605-609. doi:10.1093/qjmed/hcu239
Article. .
Nunes, J. F. G., Zhang, H., Stebbing, J., Angelopoulos, N., & Giamas, G. (2014). Silac-based analysis reveals a unique phosphoproteomic-signature of her2-resistant breast cancer cells. In Anticancer Research Vol. 34 (pp. 5900). Sithonia, Greece: International Institute of Anticancer Research.
Conference publication. .
Xu, Y., Zhang, H., Vorgias, C., Stebbing, J., & Giamas, G. (2014). Positioning LMTK3 on the map of oncogenic signaling cascades and elucidating its role in invasion and metastasis in breast cancer. In Anticancer Research Vol. 34 (pp. 5923-5924). Sithonia, Greece: International Institute of Anticancer Research.
Conference publication. .
Mazarakis, N. K., Smith, S., Vraka, A., Macarthur, D., Grundy, R., Stebbing, J., & Giamas, G. (2014). Abstract 5268: The expression of lemur tyrosine kinase-3 in high grade pediatric tumors. Cancer Research, 74(19_Supplement), 5268. doi:10.1158/1538-7445.am2014-5268
Article. .
Xu, Y., Zhang, H., & Giamas, G. (2014). Targeting lemurs against cancer metastasis. Oncotarget, 5(14), 5192-5193. doi:10.18632/oncotarget.2271
Article. .
Xu, Y., Zhang, H., Lit, L. C., Grothey, A., Athanasiadou, M., Kiritsi, M., . . . Giamas, G. (2014). The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin ß1. Science signaling, 7(330), ra58 ( pages). doi:10.1126/scisignal.2005170
Article. .
Stebbing, J., Lit, L. C., Zhang, H., Darrington, R. S., Melaiu, O., Rudraraju, B., & Giamas, G. (2014). The regulatory roles of phosphatases in cancer. Oncogene, 33(8), 939-953. doi:10.1038/onc.2013.80
Article. .
Winder, T., Giamas, G., Wilson, P. M., Zhang, W., Yang, D., Bohanes, P., . . . Lenz, H. -J. (2014). Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen. The Pharmacogenomics Journal, 14(1), 28-34. doi:10.1038/tpj.2013.8
Article. .
Melaiu, O., Stebbing, J., Lombardo, Y., Bracci, E., Uehara, N., Bonotti, A., . . . Landi, S. (2014). MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma. PLoS ONE, 9(1), pages. doi:10.1371/journal.pone.0085935
Article. .
Magturo, S., Giamas, G., Mallick, S., Layton, A., Stebbing, J., Lenz, H. -J., & LaBonte, M. J. (2014). Evaluation of LMTK3 expression and tumor phenotype in estrogen-dependent colorectal cancer. In CANCER RESEARCH Vol. 74. doi:10.1158/1538-7445.AM2014-4213
Conference publication. .
Zhang, H., Stebbing, J., Xu, Y., & Giamas, G. (2014). Global mapping of tyrosine kinase signalling in breast cancer by combined use of RNAi and SILAC quantitative proteomics. In CANCER RESEARCH Vol. 74. doi:10.1158/1538-7445.AM2014-1606
Conference publication. .

2013

Fentiman, I., Cartlidge, C., Dixon, J. M., Giamas, G., & Kiritsi, M. (2013). Journal Watch: Our panel of experts highlight the most important research articles across the spectrum of topics relevant to the field of breast cancer management. Breast Cancer Management, 2(6), 455-457. doi:10.2217/bmt.13.60
Article. .
Stebbing, J., Filipovic, A., & Giamas, G. (2013). Claudin-1 as a promoter of EMT in hepatocellular carcinoma. Oncogene, 32(41), 4871-4872. doi:10.1038/onc.2012.591
Article. .
Wakatsuki, T., LaBonte, M. J., Bohanes, P. O., Zhang, W., Yang, D., Azuma, M., . . . Lenz, H. -J. (2013). Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States. Molecular Cancer Therapeutics, 12(10), 2261-2272. doi:10.1158/1535-7163.MCT-12-1134
Article. .
Zhang, H., Koo, C. Y., Stebbing, J., & Giamas, G. (2013). The dual function of KSR1: a pseudokinase and beyond. Biochemical Society Transactions, 41(4), 1078-82. doi:10.1042/BST20130042
Article. .
Stebbing, J., Filipovic, A., Lit, L. C., Blighe, K., Grothey, A., Xu, Y., . . . Giamas, G. (2013). LMTK3 is implicated in endocrine resistance via multiple signaling pathways. Oncogene, 32(28), 3371-3380. doi:10.1038/onc.2012.343
Article. .
Filipovic, A., Stebbing, J., & Giamas, G. (2013). Cancer stem cells - therapeutic targeting or therapy?. Lancet Oncology, 14(7), 579-580. doi:10.1016/S1470-2045(13)70258-4
Article. .
Zhang, H., Stebbing, J., Filipovic, A., Ellis, I. O., Lenz, H. -J., & Giamas, G. (2013). Abstract 4316: A dynamic interplay of KSR1, p53 and BRCA1 in breast cancer.. In Cancer Research Vol. 73 (pp. 4316). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2013-4316
Conference publication. .
Xu, Y., Filipovic, A., Zhang, H., Lit, L. C., Lombardo, Y., Stebbing, J., & Giamas, G. (2013). The role of LMTK3 in breast cancer cell growth and invasion. In CANCER RESEARCH Vol. 73. doi:10.1158/1538-7445.AM2013-3794
Conference publication. .
Zhang, H., Xu, Y., Filipovic, A., Lit, L. C., Koo, C. -Y., Stebbing, J., & Giamas, G. (2013). SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1. British Journal of Cancer, 109(10), 2675-2684. doi:10.1038/bjc.2013.628
Article. .
Lit, L. C., Scott, S., Zhang, H., Stebbing, J., Photiou, A., & Giamas, G. (2013). LATS2 is a modulator of estrogen receptor alpha. Anticancer Research, 33(1), 53-63.
Article. .

2012

Giamas, G., Xu, Y., Filipovic, A., Grothey, A., Coombes, C. R., & Stebbing, J. (2012). Abstract P6-04-15: The involvement of LMTK3 in endocrine resistance is mediated via multiple signaling pathways. In Cancer Research Vol. 72. American Association for Cancer Research (AACR). doi:10.1158/0008-5472.sabcs12-p6-04-15
Conference publication. .
Zhang, H., Lombardo, Y., Filipovic, A., Periyasamy, M., Coombes, R. C., Stebbing, J., & Giamas, G. (2012). Abstract P1-04-04: KSR1 is involved in functional interaction between p53 and BRCA1 and is an independent predictor of overall survival in breast cancer. In Cancer Research Vol. 72. American Association for Cancer Research (AACR). doi:10.1158/0008-5472.sabcs12-p1-04-04
Conference publication. .
Lombardo, Y., Filipovic, A., Molyneux, G., Periyasamy, M., Giamas, G., Hu, Y., . . . Coombes, R. C. (2012). Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo. Proceedings of the National Academy of Sciences, 109(41), 16558-16563. doi:10.1073/pnas.1206268109
Article. .
Xu, Y., & Giamas, G. (2012). [Editorial] Breast cancer and LMTK3: old disease, new target. Breast Cancer Management, 1(2), 101-103. doi:10.2217/bmt.12.23
Article. .
Schirripa, M., Loupakis, F., Cremolini, C., Dongyun, Y., Labonte, M. J., Zhang, W., . . . Lenz, H. J. (2012). PD-0016 KSR1 gene polymorphism in mcrc patients treated with first-line folfiri and bevacizumab. Annals of Oncology, 23, iv24. doi:10.1016/s0923-7534(19)66510-5
Article. .
Zhang, H., Photiou, A., Grothey, A., Stebbing, J., & Giamas, G. (2012). The role of pseudokinases in cancer. Cellular Signalling, 24(6), 1173-1184. doi:10.1016/j.cellsig.2012.01.017
Article. .
Zhang, W., Benhaim, L., Yang, D., Gerger, A., Bohanes, P. O., Páez, D., . . . Lenz, H. -J. (2012). Genetic variants of kinases suppressors of ras (KSR1) to predict survival in patients with ER-alpha positive metastatic breast cancer.. Journal of Clinical Oncology, 30(15_suppl), e11018. doi:10.1200/jco.2012.30.15_suppl.e11018
Article. .
Barzi, A., Wakatsuki, T., Zhang, W., Yang, D., Loupakis, F., Ning, Y., . . . Lenz, H. -J. (2012). Prognostic value of lemur tyrosine kinase-3 (LMTK3) polymorphism in Japanese (J) patients (PTS) with localized gastric adenocarcinoma (GAC).. Journal of Clinical Oncology, 30(15_suppl), 4088. doi:10.1200/jco.2012.30.15_suppl.4088
Article. .
Benhaim, L., Loupakis, F., Zhang, W., Gerger, A., Bohanes, P. O., Páez, D., . . . Lenz, H. -J. (2012). Genetic variants of kinases suppressors of ras in KRAS-BRAF wild-type metastatic colorectal cancer patients treated with cetuximab and irinotecan. Journal of Clinical Oncology, 30(15), 3597. doi:10.1200/jco.2012.30.15_suppl.3597
Article. .
Schirripa, M., Loupakis, F., Cremolini, C., Yang, D., Labonte, M. J., Zhang, W., . . . Lenz, H. -J. (2012). KSR1 gene polymorphism in mCRC patients treated with first-line FOLFIRI and bevacizumab. Journal of Clinical Oncology, 30(15), 3546. doi:10.1200/jco.2012.30.15_suppl.3546
Article. .
Barzi, A., Wakatsuki, T., Zhang, W., Yang, D., Loupakis, F., Ning, Y., . . . Lenz, H. -J. (2012). Prognostic value of lemur tyrosine kinase-3 (LMTK3) polymorphism in Japanese (J) patients (PTS) with localized gastric adenocarcinoma (GAC). In Journal of Clinical Oncology Vol. 30 (pp. 4088). Chicago, Illinois: American Society of Clinical Oncology (ASCO). doi:10.1200/jco.2012.30.15_suppl.4088
Conference publication. .
Zhang, W., Benhaim, L., Yang, D., Gerger, A., Bohanes, P. O., Páez, D., . . . Lenz, H. -J. (2012). Genetic variants of kinases suppressors of ras (KSR1) to predict survival in patients with ER-alpha positive metastatic breast cancer. In Journal of Clinical Oncology Vol. 30 (pp. e11018 ( pages)). Chicago, Illinois: American Society of Clinical Oncology (ASCO). doi:10.1200/jco.2012.30.15_suppl.e11018
Conference publication. .
Giamas, G., Zhang, H., Zhang, W., Filipovic, A., Lenz, H. -J., & Stebbing, J. (2012). Abstract 64: Identification of novel kinases involved in Estrogen receptor-α (ERα) signalling and the development of endocrine resistance in breast cancer. In Cancer Research Vol. 72 (pp. 64). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2012-64
Conference publication. .
Zhang, H. X. J., Paez, D., Giamas, G., Filipovic, A., Yang, D., Bohanes, P., . . . Lenz, H. -J. (2012). Abstract 2670: Genetic variants in human epidermal growth factor receptor (HER) family gene predict tumor recurrence in breast cancer. In Cancer Research Vol. 72 (pp. 2670). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2012-2670
Conference publication. .
Stebbing, J., Filipovic, A., Ellis, I. O., Green, A. R., D'Silva, T. R., Lenz, H. -J., . . . Giamas, G. (2012). LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome. Breast Cancer Research and Treatment, 132(2), 537-544. doi:10.1007/s10549-011-1622-z
Article. .
Jiao, L. R., Frampton, A. E., Jacob, J., Pellegrino, L., Krell, J., Giamas, G., . . . Castellano, L. (2012). MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors. PLoS ONE, 7(2), pages. doi:10.1371/journal.pone.0032068
Article. .
Zhang, W., Gerger, A., Labonte, M. J., Yang, D., Bohanes, P. O., Ning, Y., . . . Lenz, H. -J. (2012). Association of gender-related tumor recurrence with a polymorphic variant of LMTK3 in stage II and III colon cancer. In Journal of Clinical Oncology Vol. 30 (pp. 454). American Society of Clinical Oncology. doi:10.1200/jco.2012.30.4_suppl.454
Conference publication. .
Wakatsuki, T., Bohanes, P. O., Zhang, W., Gerger, A., Yang, D., Ning, Y., . . . Lenz, H. -J. (2012). Use of genetic variants of LMTK3 to predict tumor recurrence in female localized gastric adenocarcinoma. In Journal of Clinical Oncology Vol. 30 (pp. 63). San Francisco, California: American Society of Clinical Oncology. doi:10.1200/jco.2012.30.4_suppl.63
Conference publication. .
Loupakis, F., Zhang, W., Gerger, A., Yang, D., Bohanes, P. O., Labonte, M. J., . . . Lenz, H. -J. (2012). LMTK3 polymorphism in patients with metastatic colon cancer.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 30. doi:10.1200/jco.2012.30.4_suppl.471
Conference publication. .

2011

Filipovic, A., Giamas, G., & Stebbing, J. (2011). The potential role of cyclooxygenase-2 (COX-2) during early breast cancer therapy. Annals of Oncology, 22(8), 1700-1702. doi:10.1093/annonc/mdr266
Article. .
Giamas, G. (2011). LMTK3: a novel therapeutic target for breast cancer. Pharmacogenomics, 12(7), 931-932. doi:10.2217/pgs.11.78
Article. .
Stebbing, J., Filipovic, A., & Giamas, G. (2011). Lemur tyrosine kinase-3 (LMTK3) in cancer and evolution. Oncotarget, 2(6), 428-9.
Article. .
Stebbing, J., Filipovic, A., & Giamas, G. (2011). [Editorial] LMTK3 and evolution. Oncotarget, 2, 428-429. doi:10.18632/oncotarget.v2i6
Article. .
Giamas, G., Filipovic, A., Jacob, J., Messier, W., Zhang, H., Yang, D., . . . Stebbing, J. (2011). Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nature Medicine, 17(6), 715-719. doi:10.1038/nm.2351
Article. .
Winder, T., Giamas, G., Zhang, W., Yang, D., Bohanes, P. O., Ning, Y., . . . Lenz, H. (2011). Use of insulin-like growth factor (IGF) pathway polymorphism IGF1R_rs2016347 to predict tumor recurrence in estrogen receptor-positive breast cancer patients. In Journal of Clinical Oncology Vol. 29 (pp. 538). Chicago, Illinois: American Society of Clinical Oncology. doi:10.1200/jco.2011.29.15_suppl.538
Conference publication. .

2010

Giamas, G., Filipovic, A., Jacob, J., Shifa, B. A., Green, A. R., Ellis, I. O., . . . Stebbing, J. (2010). Abstract S3-7: Kinome Screening for Regulators of Estrogen Receptor Identifies a Novel Kinase as a New Therapeutic Target in Breast Cancer. In Cancer Research Vol. 70. American Association for Cancer Research (AACR). doi:10.1158/0008-5472.sabcs10-s3-7
Conference publication. .
Man, Y. L., Filipovic, A., Stebbing, J., & Giamas, G. (2010). New and established targets for the treatment of breast cancer. Advances in Breast Cancer, 7(3), 10-13.
Article. .
Filipovic, A., Giamas, G., Coombes, R. C., & Stebbing, J. (2010). Gamma secretase and Notch as therapeutic targets in cancer. Advances in Breast Cancer, 7(3), 2-5.
Article. .
Giamas, G., Man, Y. L., Hirner, H., Bischof, J., Kramer, K., Khan, K., . . . Knippschild, U. (2010). Kinases as targets in the treatment of solid tumors. Cellular Signalling, 22(7), 984-1002. doi:10.1016/j.cellsig.2010.01.011
Article. .
Giamas, G., Filipovic, A., Jacob, J., & Stebbing, J. (2010). Abstract LB-226: Identification of novel kinases modulating ER: new therapeutic targets in breast cancer. In Cancer Research Vol. 70. American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am10-lb-226
Conference publication. .

2009

Castellano, L., Giamas, G., Jacob, J., Coombes, R. C., Lucchesi, W., Thiruchelvam, P., . . . Stebbing, J. (2009). The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response. Proceedings of the National Academy of Sciences, 106(37), 15732-15737. doi:10.1073/pnas.0906947106
Article. .
Giamas, G., Castellano, L., Feng, Q., Knippschild, U., Jacob, J., Thomas, R. S., . . . Stebbing, J. (2009). CK1d modulates the transcriptional activity of ERa via AIB1 in an estrogen-dependent manner and regulates ERa-AIB1 interactions. Nucleic Acids Research, 37(9), 3110-3123. doi:10.1093/nar/gkp136
Article. .

2008

Mintz, P. J., Habib, N. A., Jones, L. J., Giamas, G., Lewis, J. S., Bowen, R. L., . . . Stebbing, J. (2008). The phosphorylated membrane estrogen receptor and cytoplasmic signaling and apoptosis proteins in human breast cancer. Cancer, 113(6), 1489-1495. doi:10.1002/cncr.23699
Article. .
Castellano, L., Waxman, J., Giamas, G., Apostolopous, C., & Stebbing, J. (2008). The identification of new tumour suppressor micromas epigenetically silenced in drug resistant cancer cells. In European Journal of Cancer Supplements Vol. 6 (pp. 95). Lyon, France: Elsevier. doi:10.1016/S1359-6349(08)71541-6
Conference publication. .
Apostolopoulos, C., Castellano, L., Stebbing, J., & Giamas, G. (2008). Bendamustine as a model for the activity of alkylating agents. Future Oncology, 4(3), 323-332. doi:10.2217/14796694.4.3.323
Article. .
Brockschmidt, C., Hirner, H., Huber, N., Eismann, T., Hillenbrand, A., Giamas, G., . . . Knippschild, U. (2008). Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut, 57(6), 799-806. doi:10.1136/gut.2007.123695
Article. .
Giamas, G., Ali, S., Apostolopoulos, C., Castellano, L., Coombes, C., & Stebbing, J. (2008). The identification of new signaling pathways involved in estrogen receptor-alpha (ER alpha) transcriptional activity. In FEBS JOURNAL Vol. 275 (pp. 137). Athens, Greece.
Conference publication. .
Castellano, L., Waxman, J., Giamas, G., Apostolopoulous, C., & Stebbing, J. (2008). The identification of new tumour suppressor microRNAs epigenetically silenced in drug resistant cancer cells. In FEBS JOURNAL Vol. 275 (pp. 152). Retrieved from https://www.webofscience.com/
Conference publication.

2007

von Blume, J., Knippschild, U., Dequiedt, F., Giamas, G., Beck, A., Auer, A., . . . Seufferlein, T. (2007). Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO Journal, 26(22), 4619-4633. doi:10.1038/sj.emboj.7601891
Article. .
Apostolopoulos, C., Giamas, G., & Stebbing, J. (2007). Clinical significance of circulating tumor cells. Biomarkers in Medicine, 1(3), 341-342. doi:10.2217/17520363.1.3.341
Article. .
Giamas, G., Hirner, H., Shoshiashvili, L., Grothey, A., Gessert, S., Kühl, M., . . . Knippschild, U. (2007). Phosphorylation of CK1d: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo. Biochemical Journal, 406(3), 389-398. doi:10.1042/BJ20070091
Article. .
Giamas, G., Stebbing, J., Vorgias, C. E., & Knippschild, U. (2007). Protein kinases as targets for cancer treatment. Pharmacogenomics, 8(8), 1005-1016. doi:10.2217/14622416.8.8.1005
Article. .

2006

Wolff, S., Stöter, M., Giamas, G., Piesche, M., Henne-Bruns, D., Banting, G., & Knippschild, U. (2006). Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Letters, 580(27), 6477-6484. doi:10.1016/j.febslet.2006.10.068
Article. .
Knippschild, U., Shoshiashvili, L., Henne-Bruns, D., & Giamas, G. (2006). Regulation der Casein Kinase 1 delta (CK1δ) Aktivität durch Protein Kinase A (PKA): ein Ansatzpunkt für neue Therapiekonzepte in der Tumorbehandlung?. In Deutsche Gesellschaft für Chirurgie (pp. 143-144). Springer Berlin Heidelberg. doi:10.1007/3-540-34668-6_47
Chapter. .
Brockschmidt, C., Eismann, T., Kalthoff, H., Henne-Bruns, D., Trauzold, A., Bohm, B., . . . Knippschild, U. (2006). Sensibilisierung resistenter Pankreastumorzelllinien gegenüber einer CD95 vermittelten Apoptose durch Casein Kinase 1 (CK1) spezifische Inhibitoren. In Deutsche Gesellschaft für Chirurgie (pp. 145-146). Springer Berlin Heidelberg. doi:10.1007/3-540-34668-6_48
Chapter. .

2005

Knippschild, U., Wolff, S., Giamas, G., Brockschmidt, C., Wittau, M., Würl, P. U., . . . Stöter, M. (2005). The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie, 28(10), 508-514. doi:10.1159/000087137
Article. .

Unpublished works

Gagliano, T., Ditsiou, A., Grothey, A., & Giamas, G. (n.d.). Human kinome siRNA screening to identify novel targets implicated in fibroblast-mediated triple negative breast cancer cells invasion. Poster session presented at the meeting of EACR conference series goodbye flat biology: models, mechanisms and microenvironment.
Poster. .
Knippschild, U., Shoshiashvili, L., Henne-Bruns, D., & Giamas, G. (n.d.). Einfluss zellulärer Kinasen auf die Aktivität von CK1δ in pankreatischen Tumorzelllinien. In Deutsche Gesellschaft für Chirurgie (pp. 105-106). Springer Berlin Heidelberg. doi:10.1007/978-3-540-71123-0_33
Chapter. .