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Module details for 2017/18.

15 credits

FHEQ Level 6

Module Outline

This module takes an up-to-the-minute look at the molecular mechanisms controlling RNA expression in prokaryotes and eukaryotes, focusing largely on gene transcription but also examining RNA processing events in eukaryotes. We will examine the way in which bacteria control gene expression in response to different environmental cues through precisely co-ordinated transcription regulatory networks, and investigate the way in which eukaryotic transcriptional regulators control RNA polymerase recruitment and retention and modulate chromatin structure during transcriptional activation and repression. Understanding these processes and mechanisms is fundamental for the study of health and disease, for example to aid the development of new antibiotics and decipher how gene regulatory networks are perturbed during cancer development.

Module learning outcomes

Describe the factors and molecular mechanisms involved in the regulation of transcription and processing.

Compare and contrast the mechanisms involved in controlling prokaryotic and eukaryotic RNA expression.

Critically evaluate and apply information extracted from the relevant scientific literature.

Demonstrate an understanding of the key scientific techniques used to study transcription and processing and their application to studies to interpret and analyse data obtained using these techniques.

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Timing

Submission deadlines may vary for different types of assignment/groups of students.

Weighting

Coursework components (if listed) total 100% of the overall coursework weighting value.

How to read the week pattern

The numbers indicate the weeks of the term and how many events take place each week.

Prof Michelle West

Assess convenor, Convenor
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Dr Mark Paget

Assess convenor
/profiles/117009